The chemistry sets work as an [INPUT]=[OUTPUT] scenario where you get the output after the input criteria is met. Theoretically I think you could apply the strangifier for the Pomson to a Collector's grade Pomson, but I'm not completely certain. From there I know you can add a Pro/Specialized kit to the item.
I don't see a lot of value in the "Collector's" grade items because they are not strange, and really I only see Strange items as being worth something when a Pro/Specialized kit is attached. It's just my person POV, but I think the stat tracking was one of the best things they have done for TF2. The collector's stuff seems like a step sideways, something that people with lots of loot may pursue, but the average person has next to no desire for.